Western-South African area covers the middle and southern part of Africa, the islands Saint Helena and Ascension in Atlantic Ocean. It belongs to the botanically richer areas of Paleotropis. We can find here 8 endemic families and specific endemism is expressive here. In this sub-region are unmistakable developmental relationships to the Neotropis and the southern part is influenced by Capensis.
- AIZOON CANARIENSE L. – Canarian Aizoon, Purslane-leaved Aizoon
- ALOE ARBORESCENS Miller – Krantz Aloe
- ALOE JUCUNDA Reynolds
- ARABIS ALPINA L. – Alpine Rockcress
- BLUTAPARON VERMICULARE (L.) Mears – Silverweed, Saltweed, Samphire
- BRILLANTAISIA OWARIENSIS P. Beauv.
- BULBINE FRUTESCENS (L.) Willd. – Stalked Bulbine
- CEROPEGIA STAPELIIFORMIS Haw.
- CYPERUS ERAGROSTIS Lam. – Drain Flat Sedge, Pale Galingale, Umbrella Sedge
- DALBERGIA ECASTAPHYLLUM (L.) Taub. – Coinvine
- ERICA ARBOREA L. – Brierroot, Tree Heath
- EUPHORBIA AERUGINOSA Schweick.
- EUPHORBIA SUCCULENTA (Schweick.) Bruyns
- GLEICHENIA POLYPODIOIDES (L.) Sm. – Coral Fern
- GOMPHOCARPUS FRUTICOSUS (L.) W. T. Aiton – Narrow-leafed Cotton Bush, Swan Plant, Bristle-fruited Silkweed, Mobydick
- HUERNIA BARBATA (Masson) Haw.
- HUERNIA HISLOPII Turrill – Carrion Flower, Dragon-flower
- HUERNIA INSIGNIFLORA Maass – Cherry Donut
- HUERNIA THURETII Cels ex Hérincq
- IPOMOEA PES-CAPRAE (L.) R. Br. – Railroad Vine, Bayhops
- IPOMOEA QUAMOCLIT L. – Cypress Vine, Cardinal Creeper, Cardinal Vine, Star Glory, Hummingbird Vine, Cypressvine Morning Glory
- JUSTICIA SCHIMPERIANA (Hochst. ex Nees) T. Anderson
- MERREMIA UMBELLATA (L.) Hallier f. – Hogvine
- MESEMBRYANTHEMUM CRYSTALLINUM L. – Common Iceplant, Crystalline Iceplant
- NOTHOLAENA MARANTAE (L.) Desv.
- OPHIOGLOSSUM VULGATUM L. – English Adder’s-tongue, Southern Adder’s-tongue
- ORBEA SCHWEINFURTHII (A. Berger) Bruyns
- ORBEANTHUS HARDYI (R. A. Dyer) L. C. Leach
- PLANTAGO AFRA L. – African Plantain, Glandular Plantain, Black Psyllium
- PLEOPELTIS POLYPODIOIDES (L.) E. G. Andrews et Windham – Resurrection Fern
- POLYPODIUM VULGARE L. – Common Polypody
- PYROSTRIA BIBRACTEATA (Baker) Cavaco
- RUMOHRA ADIANTIFORMIS (G. Forst.) Ching – Leather Fern, Leatherleaf Fern
- SESUVIUM PORTULACASTRUM (L.) L. – Seaside Purslane, Shoreline Purslane, Sea Purslane
- SPATHODEA CAMPANULATA P. Beauv. – African Tulip, Fountain Tree, Fireball
- STAPELIA ERECTIFLORA N. E. Br.
- STAPELIA HIRSUTA L. – Starfish Flower, Carrion Plant
- THYMUS SERRULATUS Hochst. ex Benth. – Thyme
- TODEA BARBARA (L.) T. Moore – King Fern, Crepe Fern
- VIOLA ABYSSINICA Steud. ex Oliv. – Violet